The context for regional development is constantly being reshaped by the globalised economic system, which affects regions differently, with the attendant risk that disparities will widen. This study examines the coherence of Irish regional policy in this evolving context. It develops and applies a model of policy coherence to Irish regional policy in relation to investment planning processes, spatial planning and territorial governance. The dominant regional economic growth theories and the influential concepts of territorial cohesion, regional competitiveness and polycentric spatial development are critically reviewed. The rationale for regional policy is re-examined; a typology of regional policy interventions and territorial governance arrangements is outlined, and its relevance to Ireland is assessed. The study combines an analysis of documentary sources and statistical trends with the outcomes of 24 interviews with leading personnel in four categories – government departments and agencies, subnational public bodies, selected academic experts and social partner bodies – all of whom are active players in regional policy development, implementation and evaluation processes. Among the key findings are that regional policy goals are subsidiary to national goals and that Irish regional policy lacks coherence with related policies. The study finds a need for an enhanced role for region-level bodies that would greatly improve the territorial co-ordination of sectoral policies. It concludes that the policy coherence framework is a useful one that could be applied more generally in reviewing public policies.